Posted on 03/03/2010
Academics from the School of Biological Sciences at Royal Holloway, University of London have been awarded grants of up to £850k (total funding to all partners EUR2.8 million ) to explore protein-protein interactions and pathways as a means to understand the crosstalk between plant, animal or human hosts and Salmonella. Multidisciplinary team is led by Professor Vincent Jansen (School of Biological Sciences) and includes Prof Alex Gammerman (Computer Science) Dr Mikhail Soloviev (School of Biological Sciences) and includes colleagues from both departments as well as the Veterinary Laboratories Agency. Additional funding is provided by BBSRC to another UK partners (St George's, University of London). Total ERASysBio+ funding for this project to all partners was EUR2.8million.
Salmonella are Gram-negative bacterial pathogens capable of infecting a wide range of hosts, including humans, pigs, cows, chicken and even plants. Salmonella typhimurium is the causative agent of various human and animal diseases, reaching from enteritis to typhoid fever. According to the World Health Organisation, Salmonellosis is the most frequent food-borne disease with around 1,5 billion infections world-wide yearly. Although hygiene conditions have improved considerably, the number of Salmonella infections has increased over the last decade due to antimicrobial resistance and the ability of Salmonella to hide inside host cells. Novel approaches are needed to address this global health problem. Salmonella replicates within host cells in a membrane-bound compartment and is dependent on tolerance and resources of the host cell. To ensure survival and propagation, Salmonella therefore secretes proteins into the host cytoplasm using a type III secretion system. Some of the roles of these proteins are beginning to be revealed, in particular in modulating key host signal transduction pathways. However, to fully grasp the mechanisms of host-pathogen response, we need to take a system-wide view and determining the whole network of interactions between Salmonella proteins and the host proteins. Such deep insight will yield new approaches to target the pathogens. The identification of global networks of protein-protein interactions has been accelerated in recent years by the development of high-throughput technologies such as transcriptomics and proteomics.
ERASysBio+ is a European Transnational Funding and Research programme
Royal Holloway’s School of Biological Sciences is ranked joint 3rd in the UK in the 2008 Research Assessment Exercise (RAE).
St George's BIOMICS centre is the world’s first purpose-built facility combining genomics, transcriptomics, proteomics and metabolomics on a clinical site. This facility provides the opportunity to carry out integrated analysis of the molecular basis of complex disease processes in a custom-built facility.
Veterinary Laboratories Agency (VLA) is an executive agency of the Department for Environment, Food & Rural Affairs (Defra) and is well known as a centre of scientific excellence. For over 100 years, VLA has been delivering research, surveillance and laboratory services for animal and public health