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Institute of Cardiovascular Research

Institute of Cardiovascular Research

The Institute aims to bring investigators interested in all aspects of cardiovascular research under one umbrella providing them with infrastructure as well as network support. Its aim is to become an international centre of excellence in the field of cardiovascular medicine.

Realising that patient care improves when clinicians are immersed in a research environment, Ashford & St Peters’ Hospital led a ground breaking partnership with Royal Holloway to establish ICR2UL in early 2015. This is one of the first academic institutes to be created by a district general hospital in a science partnership with an internationally acclaimed University. ICR2UL has recently also partnered with local Cardiovascular Clinical Advisory Groups. Other NHS clinical facilities are expected to join this institute in the very near future.

It is expected that interaction between leading cardiovascular researchers and NHS clinical staff will result not only in improved care to patients and better clinical outcomes but also generate original research that can translate from the laboratory to the bedside.

The institute Manager, Kate Sargeant can help you with any questions you have.

Chairman

Professor Christopher Fry

Professor Christopher Fry chairs the Institute and works with a steering group to map strategy.  He is also chair of Applied Physiology in the School of Physiology, Pharmacology & Neuroscience at the University of Bristol.  

Chris has held past posts at St Thomas’ Hospital, University College London and Surrey University and retains strong research collaborations with Surrey.  His research interests centre around disorders of excitation-contraction in the heart and visceral smooth muscle and their relation to organ pathologies. He also has an interest in optimising cardiovascular system function in patients undergoing major surgery, as part of the enhanced recovery programme.

Selected References

Fry CH, Gray RP, Dhillon PS, Jabr RI, Dupont E, Patel PM, Peters NS.   Architectural correlates of myocardial conduction: changes to the topography of cellular coupling, intracellular conductance, and action potential propagation with hypertrophy in Guinea-pig ventricular myocardium.  Circ Arrhythm Electrophysiol 2014; 7: 1198-1204.

Dhillon PS, Chowdhury RA, Patel PM, Jabr R, Momin AU, Vecht J, Gray R, Shipolini A, Fry CH, Peters NS.   Relationship between connexin expression and gap-junction resistivity in human atrial myocardium. Circ Arrhythm Electrophysiol 2014; 7: 321-329.

Dhillon PS, Gray R, Kojodjojo P, Jabr R, Chowdhury R, Fry CH, Peters NS.   Relationship between gap-junctional conductance and conduction velocity in mammalian myocardium.  Circ Arrhythm Electrophysiol 2013; 6: 1208-1214.

Jones C, Kelliher L, Dickinson M, Riga A, Worthington T, Scott MJ, Vandrevala T, Fry CH, Karanjia N, Quiney N.   Randomised clinical trial on enhanced recovery versus standard care following open liver resection. Br J Surg 2013; 100: 1015-1024.

Fry CH, Salvage SC, Manazza A, Dupont E, Labeed FH, Hughes MP, Jabr RI.   Cytoplasm resistivity of mammalian atrial myocardium determined by dielectrophoresis and impedance methods.  Biophys J. 2012; 103: 2287-2294.

Director

The Director of the Institute is Professor Pankaj Sharma. In addition to being its director he is also a consultant neurologist at Imperial College Healthcare NHS Trust.

Professor Sharma holds a University of London Chair of Neurology at Royal Holloway. He is a former British Heart Foundation Clinician Scientist at Cambridge and a Fulbright Scholar at Harvard Medical School. He holds double doctorates from both the University of Cambridge and University of London. Most recently he led the internationally renowned Imperial College Cerebrovascular Research Unit at Imperial College London.

Professor Sharma’s research seeks to use genetics, genomics and proteomics to advance human understanding of cerebrovascular disease in three key areas: prediction, diagnosis and treatment of stroke at the molecular level.  He has a particular interest in the genetics of stroke in ethnic minorities, particularly South Asians and Middle Eastern populations.

He holds doctorates from the universities of London (MD) and Cambridge (PhD).

Principal Investigators

Dr Thang S Han

Dr Thang S Han trained in medicine at the University of Cambridge and in endocrinology at University College London Hospitals. He is currently consultant physician and endocrinologist at Ashford and St Peter's NHS Foundation Trust. His research interests are wide ranging covering from aetiology to health consequences of obesity and its prevention and treatment. Dr Han has published over 100 peer-reviewed papers (H-index: 44, citations: 9,700). His current research focuses on cardiometabolic risk in middle-aged and elderly European men and in cancer survivors.

Selected publications
Han TS, Lee DM, Lean MEJ, Finn JD, O’Neill TW, Bartfai G, Forti G, Giwercman A, K Kula, N Pendleton, Punab M, Rutter MK, Vanderschueren D, Huhtaniemi IT, Wu FCW, Casanueva F and the EMAS Study Group. Associations of obesity with socioeconomic and lifestyle factors in middle-aged and elderly men: European Male Aging Study (EMAS). European Journal of Endocrinology 2015; 172:59-67.

Han TS, Conway GS, Willis DS, Krone N, Rees DA, Stimson RH, Arlt W, Walker BR, Ross RJ, and the United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE). Relationship between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE). Journal of Clinical Endocrinology and Metabolism 2014; 99:E1547-E1555.

Han TS, Walker BR, Arlt W, Ross RJ. Treatment and health outcomes in adults with congenital adrenal hyperplasia. Nature Reviews Endocrinology 2014; 10:115-124.

Han TS, Krone N, Willis DS, Conway GS, Hahner S, Rees DA, Stimson RH, Walker BR, Arlt W, Ross RJ and the United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE). Quality of life relates to glucocorticoid treatment regimen, adiposity and insulin resistance in adults with congenital adrenal hyperplasia: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE). European Journal of Endocrinology 2013; 168:887-893.

Han TS, Stimson RH, Rees DA, Krone N, Willis DS, Conway GS, Arlt W, Walker BR, Ross RJ, and the United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE). Glucocorticoid treatment regimen and health outcomes in adults with congenital adrenal hyperplasia. Clinical Endocrinology 2013; 78:197-203.

Han TS, Tajar A, Huhtaniemi IT, Forti G, O’Neill TW, Lee DM, Silman AJ, Finn JD, Bartfai G, Boonen S, Casanueva F, Giwercman A, Kula K, Lean MEJ, Pendleton N, Punab M, Vanderschueren D, Wu FCW and the EMAS Group. Impaired quality of life and sexual function in overweight and obese men: the European Male Ageing Study. European Journal of Endocrinology 2011; 164:1003-1011.


Professor Dawn Langdon

Professor of Neuropsychology, Royal Holloway, University of London, UK

Dawn Langdon completed her training as a clinical psychologist at Oxford University and theDr Dawn Langdon Institute of Psychiatry, London. She worked as a clinical neuropsychologist at the National Hospital for Neurology and Neurosurgery, Queen Square, London for sixteen years, obtaining a PhD on reasoning in organic brain syndromes from the Institute of Neurology and registration as both a neuropsychologist and a health psychologist.

She is now Professor of Neuropsychology and Director of Health and Medicine at Royal Holloway, University of London. Her current work includes studying cognitive and other psychological impacts of TIA’s. She is Mental Health Work Package Lead on the NHS England Community Neurology Project; her contribution includes defining services for cognitive and emotional aspects of stroke, among other conditions, for the Project’s commissioners’ toolkit (http://www.neural.org.uk/nhs-england-community-project-for-neurology).

She is neuropsychology lead on a number of multinational trials for the pharmaceutical industry. She has worked extensively on psychological aspects of MS, including measurement of cognition and it’s relation to pathology and other disease variables. She is also investigating how risks and benefits of MS medication are best communicated to patients.

Her research also includes work on stroke patients in collaboration with other investigators within the ICR2UL.

She has published over 60 peer-review articles and has an h-index of 30. She is a frequent contributor to international scientific meetings and committees and is a Trustee of the UK MS Trust, with whom she has authored the MS cognition website www.stayingsmart.org.uk. She is co-chair of Brief International Cognitive Assessment for MS initiative (www.BICAMS.net) and Secretary of the International MS Cognition Society (www.IMSCOGS.com).

Dr Aigul Baltabaeva

Dr Aigul Baltabaeva has graduated from Kyrgyz State Medical school. She divides her time as a Consultant Cardiologist between Royal Brompton and Harefield Hospital and Ashford and1623_D11_0006 St Peter's Hospital. Her main subspecialty interest is in cardiac imaging including all modalities of echocardiography and cardiac magnetic resonance imaging. She has broad research background and maintains academic interest in cardiology in busy clinical environment.  

Her main research interest is focused on studying changes in cardiac geometry and function in cardiovascular disease. Aigul’s PhD thesis looking at cardiac remodelling in hypertension received numerous awards and distinctions at international level. Dr Baltabaeva has an experience of a core-lab cardiologist for multicentre European study looking at regression of hypertrophic cardiomyopathy in patients with Friedreich's ataxia. Currently Dr Baltabaeva is a principal investigator of major study looking at the incidence of significant mitral valve incompetence in acute heart failure. She maintains close connections with native Kyrgyzstan and just completed observational research study in remote rural district on the prevalence of cardiac disease amongst indigenous population.  

Mike Mahmoudi

My research interests are the role of DNA damage and repair mechanisms in the pathogenesis of atherosclerosis as well as the potential for utilising circulating micro-RNAs in elucidating the pathophysiology of isolated coronary calcification.

I am currently the principal investigator of a study examining the expression of genes involved in the DNA damage and repair-signaling pathways in peripheral blood mononuclear cells (PBMCs) in patients with coronary artery disease and determining whether the expression of such genes can be correlated with plaque anatomy as assessed with frequency-domain optical coherence tomography.

I am also the principal investigator of a study investigating the potential for a “micro-RNA-signature” in patients with isolated coronary artery calcification as measured by CT coronary angiography. microRNAs are isolated from PBMCs for microarray analysis to predict potential micro-RNA targets and to examine the molecular/signalling pathways that characterise the pathophysiology of isolated coronary artery calcification in humans.

Publications

Original articles

1. Ota H, Mahmoudi M, Torguson R, Satler LF, Suddath WO, Pichard AD, Waksman R (2015). Safety and efficacy of everolimus-eluting stents for bare-metal in-stent restenosis. Cardiovasc Revasc Med, 16, 328-330

2. Tian W, Mahmoudi M, Lhermusier T, Pendyala LK, Kiramijyan S, Saar M, Ota H, Chen F, Torguson R, Suddath WO, Satler LF, Pichard AD, Waksman R (2015). Clinical outcomes of first- and second-generation drug-eluting stents in patients undergoing rotational atherectomy for heavily calcified coronary lesions. Cardiovasc Revasc Med, 16, 147-150

3. Ota H, Mahmoudi M, Kitabata H, Torguson R, Chen F, Satler LF, Suddath WO, Pichard AD, Waksman R (2015). Safety and efficacy of limus-eluting stents and balloon angioplasty for sirolimus-eluting in-stent restenosis. Cardiovasc Revasc Med, 16, 84-89

4. Williams TM, Waksman R, De Silva K, Jaques A, Mahmoudi M (2015). Ischemic preconditioning-an unfulfilled promise. Cardiovasc Revasc Med, 16, 101-108

5. De Silva K, Mahmoudi M (2015). Isolated coronary artery aneurysms presenting with ST-elevation myocardial infarction – a case of when less is more. Coron Artery Dis, 26, 88-90

6. Zeb M, Mahmoudi M, Garty F, Bannister C, Reddiar R, Nicholas Z, Crouch R, Heyworth J, Curzen N (2014). Detection of regional myocardial ischemia by a novel 80-electrode body surface Delta map in patients presenting to the emergency department with cardiac sounding chest pain. Eur J Emerg Med, 21, 89-97

7. Delhaye C, Kpogbemabou N, Modine T, Lemesle G, Staels B, Mahmoudi M, Tailleux A, Luc G, Bauters C, Lablanche J (2013). Long-term prognostic value of pre-procedural adiponectin levels in patients undergoing percutaneous coronary intervention. Inter J Cardiol, 168, 4921-4924

8. Mahmoudi M, Delhaye C, Waksman R (2012). Hypothermia therapy: Neurological and Cardiac Benefits. J Am Coll Cardiol, 17, 197-210

9. Mahmoudi M, Hauville C, Gaglia MA, Sardi G, Torguson R, Xue Z, Satler LF, Suddath  WO, Pichard AD, Waksman R (2012). The impact of intra-aortic balloon counter-pulsation on in-hospital mortality in patients presenting with anterior ST-elevation myocardial infarction without cardiogenic shock. Cardiovasc Revasc Med, 13, 328-330

10. Mahmoudi M, Harden S, Abid N, Peebles C, Nicholas Z, Jones T, McKenzie D, Curzen N (2012). Toponin positive chest pain with unobstructed coronary arteries: Definitive differential diagnosis using cardiac MRI. Br J Radiol, 85, e461-466

11. Mahmoudi M, Waksman R (2012). Glycoprotein IIb/IIIa inhibitors and bivalirudin in patients undergoing percutaneous coronary intervention. Minerva Cardioangiol, 60, 95-100

12. Maluenda G, Ben-Dor I, Gaglia MA, Wakabayashi K, Mahmoudi M, Sardi G, Laynez-Carnicero A, Torguson R, Xue Z, Margulies AD, Suddath WO, Kent KM, Bernardo NL, Satler LF, Pichard AD, Waksman R (2012). Clinical outcomes and treatment after drug-eluting stent failure: the absence of traditional risk factors for in-stent re-stenosis. Circ Cardiovasc Interv, 5, 12-19

13. Ben-Dor I, Maluenda G, Mahmoudi M, Torguson R, Xue Z, Bernardo NL, Lindsay J, Satler LF, Pichard AD, Waksman R (2012). A novel, minimally invasive access technique versus standard 18-gauge needle set for femoral access. Catheter Cardiovasc Interv, 79, 1180-1185

14. Mahmoudi M, Waksman R (2012). Bifurcation stenting: The current state of play. Cardiovasc Revasc Med, 13, 51-57

15. Wakabayashi K, Pakala R, Mahmoudi M, Watanabe T, Mori H, Iso Y, Suzuki H (2012). Novel technologies and future perspectives of drug eluting stents. Translational Med, S:7

16. Mahmoudi M, Hill P, Xue Z, Torguson R, Ali G, Boyce SW, Baffi AS, Corso PJ, Waksman R (2011). Patients with severe asymptomatic carotid artery stenosis do not have a higher risk of stroke and mortality following coronary artery bypass surgery. Stroke, 42, 2801-2805  

17. Mahmoudi M, Delhaye C, Wakabayashi K, Ben-Dor I, Gonzalez M, Maluenda G, Gaglia M, Torguson R, Xue Z, Satler L, Suddath W, Kent K, Pichard A, Waksman R (2011). Outcomes after unrestricted use of everolimus-eluting stent compared to paclitaxel- and sirolimus-eluting stents. Am J Cardiol, 107, 1757-1762

18. Mahmoudi M, Syed A, Ben-Dor I, Gonzalez M, Maluenda G, Gaglia M, Sardi G, Wakabayashi K, Torguson R, Xue Z, Satler L, Suddath W, Pichard A, Waksman R (2011). Safety and efficacy of clopidogrel reloading in patients on chronic clopidogrel therapy who present with an acute coronary syndrome and undergo percutaneous coronary intervention. Am J Cardiol, 107, 1779-1782

19. Mahmoudi M, Delhaye C, Wakabayashi K, Torguson R, Xue Z, Satler L, Suddath W, Kent K, Pichard A, Waksman R (2011). Integrelin in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction. Journal of Interv Cardiol, 24, 351-356

20. Mahmoudi M, Delhaye C, Waksman R (2011). Safety and efficacy of drug-eluting and bare-metal stents in acute coronary syndrome. Cardiovasc Revasc Med, 12, 385-390

21. Gaglia MA JR, Torguson R, Pakala R, Xue Z, Sardi G, Mahmoudi M, Suddath W, Kent K, Satler LF, Pichard A, Waksman R (2011). Relation of body mass index on-treatment (clopidogrel+aspirin) platelet reactivity. Am J Cardiol, 108, 766-771

22. Belle L, Mahmoudi M, Delhaye C, Ben-Dor I, Maluenda G, Gaglia M, Torguson R, Satler LF, Pichard A, Waksman R (2011). Do Patients with drug-eluting stent thrombosis have a similar prognosis to patients presenting with ST-elevation myocardial infarction of de novo lesions? Journal of Interv Cardiol, 24, 320-325

23. Wakabayashi K, Delhaye C, Mahmoudi M, Belle L, Ben-Dor I, Gaglia MA, Satler LF, Kent KM, Pichard AD, Lindsay J, Waksman R (2011). Impact of drug-eluting stent type on periprocedural myocardial necrosis. Eurointervention, 7, 136-142

24. Wakabayashi K, Romaguera R, Laynez-Carnicero A, Maluenda G, Ben-Dor I, Sardi G, Mahmoudi M, Gonzalez MA, Delhaye C, Torguson R, Xue Z, Suddath WO, Satler LF, Kent KM, Pichard AD, Lindsay J, Waksman R (2011). Impact of smoking on acute phase outcomes of myocardial infarction. Coron Artery Dis, 22, 217-222   

25. Ben-Dor I, Mahmoudi M, Pichard AD, Satler LF, Waksman R (2011). Optical coherence tomography – A new imaging modality for plaque characterisation and stent implantation. Journal of Interv Cardiol, 24, 184-192

26. Mahmoudi M, Syed A, Waksman R (2011). The role of percutaneous circulatory assist devices in acute myocardial infarction and high-risk percutaneous coronary intervention in the 21st century. Cardiovasc Revasc Med, 12, 237-242

27. Gaglia MA Jr, Torguson R, Xue Z, Gonzalez MA, Ben-Dor I, Maluenda G, Mahmoudi M, Sardi G, Wakabayashi K, Kaneshige K, Suddath WO, Kent KM, Satler LF, Pichard AD, Waksman R (2010). Effect of insurance type on adverse cardiac events after percutaneous coronary intervention. Am J Cardiol, 107, 675-680

28. Gaglia MA Jr, Torguson R, Gonzalez MA, Ben-Dor I, Maluenda G, Collins SD, Syed AI, Delhaye C, Wakabayashi K, Belle L, Mahmoudi M, Hanna N, Xue Z, Kaneshige K, Suddath WO, Kent KM, Satler LF, Pichard AD, Waksman R (2010). Correlates and consequences of gastrointestinal bleeding complicating percutaneous coronary intervention. Am J Cardiol, 106, 1069-1074

29. Mercer J, Cheng K, Figg N, Gorenne I, Mahmoudi M, Griffin J, Vidal-Puig A, Logan A, Murphy MP, and Bennett MR (2010). DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res, 107, 1021-1031

30. Mahmoudi M, Waksman R (2010). Drug-eluting stents for acute coronary syndromes: Should the labelling be expanded. Interv Cardiol, 2, 249-252

31. Mahmoudi M, Gorenne I, Mercer J, Figg N, Littlewood T, and Bennett MR (2008). Statins utilize a novel NBS-dependent pathway to accelerate DNA repair in vascular smooth muscle cells. Circ Res, 103, 712-725

32. Mahmoudi M, Curzen NP, and Gallagher PJ (2007). Angiogenesis: the role of inflammation and infection. Histopathology, 50, 535-546

33. Mercer J, Mahmoudi M, and Bennett MR (2007). DNA damage, p53, apoptosis and vascular disease. Mut Res, 621, 75-86

34. Mahmoudi M, Mercer J, and Bennett MR (2006). DNA damage and repair in atherosclerosis. Cardiovascular Research, 71, 259-268

35. Mahmoudi M, McDonagh S, Poole-Wilson S, and Dubrey SW (2003). Obstacles to the initiation of beta-blockers for heart failure in specialized clinic within a district general hospital. Heart, 89, 442-444

36. Meyer T, Nelstrop AE, Mahmoudi M, and Rustin GJS (2001). Weekly cisplatin and oral etoposide as treatment for relapsed ovarian cancer. Ann Oncol, 12, 1-5

37. Rustin GJS, Van Hippelstein M, Nelstrop AE, Mahmoudi M, and Meyer T (2001). Use of CA-125 to define progression of ovarian cancer in patients with persistently elevated levels. J Clin Oncol, 19, 4054-4057

Dr Michael Wood MBBS, BSc, PhD, FRCP

Michael Wood is the Clinical lead for Respiratory Medicine at Ashford and St Peters Hospitals (ASPH) and a Training Programme Director for Core Medical Training at Health Education Kent, Surrey and Sussex. He qualified from King’s College London and trained in and around London including specialist training at University College Hospital, The Royal Free Hospital and the London Chest Hospital. He won a Cancer Research UK Clinical Research Fellowship and gained his PhD in 2005, following research into Malignant Mesothelioma and tumour cell signalling inhibition, at the centre For Respiratory Research, UCL. After completion of his specialist training, he undertook further training in interventional bronchoscopy in Perth, Australia before returning to the UK to take up a consultant post in 2006. He has set up a highly successful endobronchial ultrasound service at ASPH and helped develop new real-time cytology techniques for bronchoscopy. There are several pharmaceutical trials running at ASPH concurrently with which he is involved, in the treatment of asthma, chronic obstructive pulmonary disease and soon to start trials with treatments of non-tuberculous mycobacterial disease and planned trails in pulmonary fibrosis. He has presented research at National and International Respiratory meetings.

Professor Pankaj Sharma - Director of ICR

Professor Pankaj Sharma is a consultant neurologist at Imperial College Healthcare NHS Trust.

Professor Sharma holds a University of London Chair of Neurology at Royal Holloway. He is a former British Heart Foundation Clinician Scientist at Cambridge and a Fulbright Scholar at Harvard Medical School. He holds double doctorates from both the University of Cambridge and University of London. Most recently he led the internationally renowned Imperial College Cerebrovascular Research Unit at Imperial College London.

Professor Sharma’s research seeks to use genetics, genomics and proteomics to advance human understanding of cerebrovascular disease in three key areas: prediction, diagnosis and treatment of stroke at the molecular level.  He has a particular interest in the genetics of stroke in ethnic minorities, particularly South Asians and Middle Eastern populations.

Kate Sargeant

Kate Sargeant is the manager of ICR2UL and is responsible for its day to day operations. In addition, Kate is the main contact person for events and lectures that are handled by the institute.

She has extensive experience in event organisation and has been a Personal Assistant for 15 years in the commercial sector.

She is also the Executive Assistant to ICR2UL Director, Professor Pankaj Sharma.

Sistema-circulatorio

Stroke

Stroke is the commonest cause of disability, the second most frequent cause of dementia and the third most common cause of death in the western world. A new stroke occurs every 3.5 minutes. Our clinical interest in stroke is to test whether current guidelines for its management stand up to scrutiny. As a major cause of death following stroke is actually due to heart disease, we are also currently using statistical techniques to determine whether we can more accurately predict the likely occurrence of a heart attack following a stroke.

Genetics

Evidence from animal work and human epidemiology (including adoption, migration and twin) studies suggests a likely genetic basis for common human stroke. Our understanding of stroke genetics has advanced considerably in recent years with the identification of monogenic stroke conditions and genes that have been associated with sporadic stroke. However, much of this work has been carried out in Caucasian populations. The World Health Organisation has estimated that around 80 per cent of the world’s burden of stroke will be placed in China and India by 2050. With this in mind, members of the Institute are creating one of the world’s largest highly phenotyped DNA repositories spanning the UK, India and Qatar. The repository is globally called the Bio-Repository of DNA in Stroke (BRAINS).

Cardiac muscle research

Ventricular and atrial arrhythmias  significantly increase patient mortality and morbidity, either directly or indirectly through conditions such as stroke. Action potential conduction failure is an important cause of arrhythmias and we are interested in its cellular and tissue basis. In particular, we measure, using biophysical techniques, changes to the electrical properties of intercellular myocardial gap junctions using tissue from normal, hypertrophied and hypertrophy-regressed hearts.  In addition we are exploring the intracellular signalling pathways that determine gap junction properties.

The enhanced recovery programme

Enhanced recovery programmes are gaining widespread acceptance as part of the peri-operative management regime to improve post-operative mortality and morbidity, as well as shorten length of stay in hospital. The programme incorporates a range of simple peri-operative techniques that includes optimisation of cardiovascular function before surgery with appropriate fluid management.  We have used the programme with a number of major surgical interventions and measured not only patient post-operative recovery variables but also the stress response during and after surgery. We are expanding the range of surgical interventions for which the programme might be tailored.

A number of publications have been produced by members of the Institute of Cardiovascular Research.

Shared genetic basis for migraine and ischemic stroke

Article title :  Shared genetic basis for migraine and ischemic stroke: a genome-wide analysis of common variants. 

Publication:   Neurology 2015 (in press).

Authors: R ainer Malik, Tobias Freilinger, Bendik S Winsvold, Verneri Anttila, Jason Vander Heiden, Matthew Traylor, Boukje de Vries, Elizabeth G Holliday, Gisela M Terwindt, Jonathan Sturm, Joshua C Bis, Jemma C Hopewell, Michel D Ferrari, Kristiina Rannikmae, Maija Wessman, Mikko Kallela, Christian Kubisch, Myriam Fornage, James F Meschia, Terho  Lehtimäki, Cathie Sudlow, Robert Clarke, Dan I Chasman, Braxton D Mitchell, Jane Maguire, Jaakko Kaprio, Martin Farrall, Olli T Raitakari, Tobias Kurth, M Arfan Ikram, Alex P Reiner, W T Longstreth Jr, Peter M Rothwell, David P Strachan, Pankaj Sharma, Sudha Seshadri , Lydia Quaye,  Lynn Cherkas , Markus Schürks, Jonathan Rosand, Lannie Ligthart, Giorgio B Boncoraglio, George Davey Smith, Cornelia M van Duijn, Kari Stefansson, Bradford B Worrall, Dale R Nyholt, Hugh S Markus, Arn MJM van den Maagdenberg, Chris Cotsapas, John A Zwart, Aarno Palotie, Martin Dichgans. 

Genetic overlap between diagnostic subtypes of ischemic stroke

Article title: Genetic overlap between diagnostic subtypes of ischemic stroke.

Publication: Stroke 2015 (in press).

Authors: Holliday E et all (incl Sharma P).

Common variation in PHACTR1

Article title: Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection.

Publication: Nat Genet 2014 (in press).

Authors: Debette S, et al (incl Sharma P).

Common variation in COL4A1/COL4A2

Article title: Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease.

Publication: Neurology 2014 (in press).

Authors: Kristiina Rannikmäe, Gail Davies, Pippa A Thomson, Steve Bevan, William J Devan, Guido J Falcone, Matthew Traylor, Christopher D Anderson, Thomas WK Battey, Farid Radmanesh, Ranjan Deka, Jessica G Woo, Lisa J Martin, Jordi Jimenez-Conde, Magdy Selim, Devin L Brown, Scott L Silliman, Chelsea S Kidwell, Joan Montaner, Carl D Langefeld, Agnieszka Slowik, Björn M Hansen, Arne G. Lindgren, James F. Meschia, Myriam Fornage, Joshua C Bis, Stéphanie Anne-Carine Debette, Mohammad Arfan Ikram, Will T Longstreth, Reinhold Schmidt, Cathy Zhang, Qiong Yang, Pankaj Sharma, Steven Kittner, Braxton D. Mitchell, Elizabeth G Holliday, Christopher Royce Levi, John Attia, Peter M Rothwell, Deborah L Poole, Giorgio B Boncoraglio, Bruce M Psaty, Rainer Malik, Natalia S. Rost, Bradford B. Worrall, Martin Dichgans, Tom Van Agtmael, Daniel Woo, Hugh S Markus, Sudha Seshadri, Jonathan Rosand, and Cathie L.M.

Effect of genetic variants .... on stroke risk

Article title: Effect of genetic variants associated with plasma homocysteine levels on stroke risk.

Publication: Stroke 2014; 45:1920-4.

Authors: Ioana Cotlarciuc, Rainer Malik, Elizabeth G. Holliday, Kourosh R Ahmadi, Guillaume Pare, Bruce M. Patsy, Myriam Fornage, Nazeeha Hasan, Paul E. Rinne, M. Arfan Ikram, Hugh S Markus, Jonathan Rosand, Braxton D. Mitchell, Steven J. Kittner, James F. Meschia, Joyce BJ van Meurs, Andre G Uitterlinden, Bradford B. Worrall, Martin Dichgans, Pankaj Sharma.

Etiologic Ischemic Stroke Phenotypes in the NINDS Stroke Genetics Network

Article title: Etiologic Ischemic Stroke Phenotypes in the NINDS Stroke Genetics Network.

Publication: Stroke 2014 (in press).

Authors: Hakan Ay, Ethem Arsava, Gunnar Andsberg, Thomas Benner, Robert Brown, Sherita Chapman Smith, John Cole, Hossein Delavaran, Martin Dichgans, Gunnar Engström, Eva Giralt-Steinhauer, Raji Grewal, Katrina Gwinn, Christina Jern, Jordi Jimenez-Conde, Katarina Jood, Michael Katsnelson, Brett Kissela, Steven Kittner, Dawn Kleindorfer, Daniel Labovitz, Silvia Lanfranconi, Jin-Moo Lee, Manuel Lehm, Robin Lemmens, Christopher Levi, Linxin Li, Arne Lindgren, Hugh Markus, Patrick McArdle, Olle Melander, Bo Norrving, Leema Reddy Peddareddygari, Annie Pedersen, Joanna Pera, Kristiina Rannikmäe, Kathryn Rexrode, J Rhodes, Stephen Rich, Jaume Roquer, Jonathan Rosand, Peter Rothwell, Tatjana Rundek, Ralph Sacco, Reinhold Schmidt, Markus Schürks, Stephan Seiler, Pankaj Sharma, Agnieszka Slowik, Cathie Sudlow, Vincent N Thijs, Rebecca Woodfield, Bradford Worrall, James Meschia.

Agreement between TOAST and CCS ischemic stroke classification

Article title: Agreement between TOAST and CCS ischemic stroke classification in a large multi-centered study: The NINDS SiGN Study.

Publication: Neurology 2014 (in press).

Authors: Patrick F McArdle, Steven J Kittner, Hakan Ay, Robert D Brown, Jr., James F Meschia, Tatjana Rundek, Sylvia Wassertheil-Smoller, Daniel Woo, Gunnar Andsberg, Alessandro Biffi, David A Brenner, John W Cole, Roderick Corriveau, Paul I.W. de Bakker, Hossein Delavaran, Martin Dichgans, Raji P. Grewal, Katrina Gwinn, Mohammed Huq, Christina Jern, Jordi Jimenez-Conde, Katarina Jood, Robert C Kaplan, Petra Katschnig, Michael Katsnelson, Daniel L Labovitz, Robin Lemmens, Linxin Li, Arne Lindgren, Hugh S Markus, Leema Reddy Peddareddygari, Annie Pedersen, Joanna Pera, Petra Redfors, Jaume Roquer, Jonathan Rosand, Natalia S Rost, Peter M Rothwell, Ralph L Sacco, Pankaj Sharma, Agnieszka Slowik, Cathie Sudlow, Vincent Thijs, Steffen Tiedt, Raffaella Valenti, and Bradford B Worrall.

Increased platelet expression of glycoprotein IIIa

Article title: Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects.

Publication:  Brit J Clin Pharm 2014 (in press).

Authors: Christopher Floyd, Timothy Goodman, Silke Becker, Nan Chen, Agnesa Mustafa, Emma Schofield, James Campbell, Malcolm Ward, Pankaj Sharma, Albert Ferro.

A novel MMP12 locus is associated with large artery atherosclerotic stroke

Article title:  A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.

Publication: PLoS Genetics 2014 (in press).

Authors: Matthew Traylor, MSc; Kari-Matti Makela; Laura Kilarski; Elizabeth G Holliday; William J Devan; Mike A Nalls; Kerri L Wiggins; Wei Zhao; Yu-Ching Cheng; Sefanja Achterberg; Rainer Malik; Cathie Sudlow; Steve Bevan; Emma Raitoharju; Niku Oksala; Vincent Thijs; Robin Lemmens; Arne Lindgren; Agniesczka Slowik; Jane M Maguire; Matthew Walters; Ale Algra; Pankaj Sharma; John R Attia; Giorgio B Boncoraglio; Peter M Rothwell; Paul I W Bakker; Joshua C Bis; Danish Saleheen; Steven J Kittner; Braxton D Mitchell; Jonathan Rosand; James F Meschia; Christopher Levi; Martin Dichgans; Terho Lehtimaki; Cathryn Lewis; Hugh Markus.

Lesion locations influencing baseline severity in ischemic stroke

Article title: Lesion locations influencing baseline severity and early recovery in ischemic stroke.

Publication: Euro J Neurol 2014 (in press).

Authors: Bentley, P.; Kumar, Guru; Rinne, Paul; Buddha, Sandeep; Kallingal, Jouher; Hookway, Cheryl; Sharma, Pankaj; Mehta, Amrish; Beckmann, Christian.

Multilocus genetic risk score associates with ischemic stroke

Article title: Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies.

Publication: Stroke 2014;45:394-402.

Authors: Malik R, Bevan S, Nalls MA, Holliday EG, Devan WJ, Cheng YC, Ibrahim-Verbaas CA, Verhaaren BF, Bis JC, Joon AY, de Stefano AL, Fornage M, Psaty BM, Ikram MA, Launer LJ, van Duijn CM, Sharma P, Mitchell BD, Rosand J, Meschia JF, Levi C, Rothwell PM, Sudlow C, Markus HS, Seshadri S, Dichgans M; Wellcome Trust Case Control Consortium 2.

Meta-analysis in over 17,900 cases of ischemic stroke reveals a novel association

Article title: Meta-analysis in over 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.

Publication: Neurology 2014;83:678-85.

Authors: Laura L Kilarski, Sefanja Achterberg, William Devan, Matthew Traylor, Rainer Malik, Arne Lindgren, Guillame Pare, Pankaj Sharma, Agnieszka Slowik, Vincent N. Thijs, Matthew Walters, Bradford B Worrall, Michele Sale, Ale Algra, Jaap Kappelle, Cisca Wijmenga, Bo Norrving, Johanna Sandling, Lars Ronnblom, An Goris, Andre Franke, Cathie Sudlow, Peter M Rothwell, Christopher Levi, Elizabeth G Holliday, Myriam Fornage, Bruce Psaty, Solveig Gretarsdottir, Unnar Thorsteindottir, Sudha Seshadri, Braxton Mitchell, Steven Kittner, Robert Clarke, Jemma Hopewell, Joshua Bis, Giorgio Boncoraglio, James Meschia, Arfan Ikram, Bjorn Hansen, Joan Montaner, Gudmar Thorleifsson, Kari Stefanson, Jonathan Rosand, Paul I W de Bakker, Martin Farrall, Martin Dichgans, Hugh S Markus, and Steve Bevan.

Prediction of stroke thrombolysis outcome using CT brain machine

Article title: Prediction of stroke thrombolysis outcome using CT brain machine learning.

Publication: Neuroimage 2014; 4; 635-640.

Authors: Paul Bentley, Jeban Ganesalingam, Anomas Dias, Kate Mahady, Sarah Epton, Paul Rinne, Pankaj Sharma, Omid Halse, Amrish Mehta, Daniel Rueckert.

Knowledge of blood pressure in a UK general public population

Article title:  Knowledge of blood pressure in a UK general public population.

Publication: J Hum Hypertens 2014 (in press).

Auithors: Slark J, Khan MS, Bentley P, Sharma P.

Shared genetic susceptibility to ischemic stroke and coronary artery disease

Article title: Shared genetic susceptibility to ischemic stroke and coronary artery disease - a genome-wide analysis of common variants.

Publication: Stroke 2014 (in press).

Authors: Dichgans M, Malik R, König IR, Rosand J, Clarke R, Gretarsdottir S, Thorleifsson G, Mitchell BD, Assimes TL, Levi C, Odonnell CJ, Fornage M, Thorsteinsdottir U, Psaty BM, Hengstenberg C, Seshadri S, Erdmann J, Bis JC, Peters A, Boncoraglio GB, März W, Meschia JF, Kathiresan S, Ikram MA, McPherson R, Stefansson K, Sudlow C, Reilly MP, Thompson JR, Sharma P, Hopewell JC, Chambers JC, Watkins H, Rothwell PM, Roberts R, Markus HS, Samani NJ, Farrall M, Schunkert H.

 

 

 

 

 

 

 

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