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Staff

 

DirectorofICR

The Director of the Institute is Professor Pankaj Sharma. In addition to being its director he is also a consultant neurologist at Imperial College Healthcare NHS Trust.

Professor Sharma holds a University of London Chair of Neurology at Royal Holloway. He is a former British Heart Foundation Clinician Scientist at Cambridge and a Fulbright Scholar at Harvard Medical School. He holds double doctorates from both the University of Cambridge and University of London. Most recently he led the internationally renowned Imperial College Cerebrovascular Research Unit at Imperial College London.

Professor Sharma’s research seeks to use genetics, genomics and proteomics to advance human understanding of cerebrovascular disease in three key areas: prediction, diagnosis and treatment of stroke at the molecular level.  He has a particular interest in the genetics of stroke in ethnic minorities, particularly South Asians and Middle Eastern populations.

He holds doctorates from the universities of London (MD) and Cambridge (PhD).

ChrisFryProfessor Christopher Fry chairs the Institute and works with a steering group to map strategy.  He is also chair of Applied Physiology in the School of Physiology, Pharmacology & Neuroscience at the University of Bristol.  

Chris has held past posts at St Thomas’ Hospital, University College London and Surrey University and retains strong research collaborations with Surrey.  His research interests centre around disorders of excitation-contraction in the heart and visceral smooth muscle and their relation to organ pathologies.  He also has an interest in optimising cardiovascular system function in patients undergoing major surgery, as part of the enhanced recovery programme.

 

 

Selected references

Fry CH, Gray RP, Dhillon PS, Jabr RI, Dupont E, Patel PM, Peters NS.   Architectural correlates of myocardial conduction: changes to the topography of cellular coupling, intracellular conductance, and action potential propagation with hypertrophy in Guinea-pig ventricular myocardium.  Circ Arrhythm Electrophysiol 2014; 7: 1198-1204.

Dhillon PS, Chowdhury RA, Patel PM, Jabr R, Momin AU, Vecht J, Gray R, Shipolini A, Fry CH, Peters NS.   Relationship between connexin expression and gap-junction resistivity in human atrial myocardium.  Circ Arrhythm Electrophysiol 2014; 7: 321-329.

Dhillon PS, Gray R, Kojodjojo P, Jabr R, Chowdhury R, Fry CH, Peters NS.   Relationship between gap-junctional conductance and conduction velocity in mammalian myocardium.  Circ Arrhythm Electrophysiol 2013; 6: 1208-1214.

Jones C, Kelliher L, Dickinson M, Riga A, Worthington T, Scott MJ, Vandrevala T, Fry CH, Karanjia N, Quiney N.   Randomised clinical trial on enhanced recovery versus standard care following open liver resection. Br J Surg 2013; 100: 1015-1024.

Fry CH, Salvage SC, Manazza A, Dupont E, Labeed FH, Hughes MP, Jabr RI.   Cytoplasm resistivity of mammalian atrial myocardium determined by dielectrophoresis and impedance methods.  Biophys J. 2012; 103: 2287-2294.

Dr Thang S Han

Thang Han

Dr Thang S Han trained in medicine at the University of Cambridge and in endocrinology at University College London Hospitals. He is currently consultant physician and endocrinologist at Ashford and St Peter's NHS Foundation Trust. His research interests are wide ranging covering from aetiology to health consequences of obesity and its prevention and treatment. Dr Han has published over 100 peer-reviewed papers (H-index: 44, citations: 9,700). His current research focuses on cardiometabolic risk in middle-aged and elderly European men and in cancer survivors.

Selected publications

Han TS, Lee DM, Lean MEJ, Finn JD, O’Neill TW, Bartfai G, Forti G, Giwercman A, K Kula, N Pendleton, Punab M, Rutter MK, Vanderschueren D, Huhtaniemi IT, Wu FCW, Casanueva F and the EMAS Study Group. Associations of obesity with socioeconomic and lifestyle factors in middle-aged and elderly men: European Male Aging Study (EMAS). European Journal of Endocrinology 2015; 172:59-67.

Han TS, Conway GS, Willis DS, Krone N, Rees DA, Stimson RH, Arlt W, Walker BR, Ross RJ, and the United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE). Relationship between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE). Journal of Clinical Endocrinology and Metabolism 2014; 99:E1547-E1555.

Han TS, Walker BR, Arlt W, Ross RJ. Treatment and health outcomes in adults with congenital adrenal hyperplasia. Nature Reviews Endocrinology 2014; 10:115-124.

Han TS, Krone N, Willis DS, Conway GS, Hahner S, Rees DA, Stimson RH, Walker BR, Arlt W, Ross RJ and the United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE). Quality of life relates to glucocorticoid treatment regimen, adiposity and insulin resistance in adults with congenital adrenal hyperplasia: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE). European Journal of Endocrinology 2013; 168:887-893.

Han TS, Stimson RH, Rees DA, Krone N, Willis DS, Conway GS, Arlt W, Walker BR, Ross RJ, and the United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE). Glucocorticoid treatment regimen and health outcomes in adults with congenital adrenal hyperplasia. Clinical Endocrinology 2013; 78:197-203.

Han TS, Tajar A, Huhtaniemi IT, Forti G, O’Neill TW, Lee DM, Silman AJ, Finn JD, Bartfai G, Boonen S, Casanueva F, Giwercman A, Kula K, Lean MEJ, Pendleton N, Punab M, Vanderschueren D, Wu FCW and the EMAS Group. Impaired quality of life and sexual function in overweight and obese men: the European Male Ageing Study. European Journal of Endocrinology 2011; 164:1003-1011.

 

Professor Dawn Langdon

Professor of Neuropsychology, Royal Holloway, University of London, UK

Dawn Langdon completed her training as a clinical psychologist at Oxford University and theDr Dawn Langdon Institute of Psychiatry, London. She worked as a clinical neuropsychologist at the National Hospital for Neurology and Neurosurgery, Queen Square, London for sixteen years, obtaining a PhD on reasoning in organic brain syndromes from the Institute of Neurology and registration as both a neuropsychologist and a health psychologist.

She is now Professor of Neuropsychology and Director of Health and Medicine at Royal Holloway, University of London. Her current work includes studying cognitive and other psychological impacts of TIA’s. She is Mental Health Work Package Lead on the NHS England Community Neurology Project; her contribution includes defining services for cognitive and emotional aspects of stroke, among other conditions, for the Project’s commissioners’ toolkit (http://www.neural.org.uk/nhs-england-community-project-for-neurology). 

She is neuropsychology lead on a number of multinational trials for the pharmaceutical industry. She has worked extensively on psychological aspects of MS, including measurement of cognition and it’s relation to pathology and other disease variables. She is also investigating how risks and benefits of MS medication are best communicated to patients.

Her research also includes work on stroke patients in collaboration with other investigators within the ICR2UL. 

She has published over 60 peer-review articles and has an h-index of 30. She is a frequent contributor to international scientific meetings and committees and is a Trustee of the UK MS Trust, with whom she has authored the MS cognition website www.stayingsmart.org.uk. She is co-chair of Brief International Cognitive Assessment for MS initiative (www.BICAMS.net) and Secretary of the International MS Cognition Society (www.IMSCOGS.com).


 Dr Aigul Baltabaeva

 

Dr Aigul Baltabaeva has graduated from Kyrgyz State Medical school. She divides her time as a Consultant Cardiologist between Royal Brompton and Harefield Hospital and Ashford and1623_D11_0006 St Peter's Hospital. Her main subspecialty interest is in cardiac imaging including all modalities of echocardiography and cardiac magnetic resonance imaging. She has broad research background and maintains academic interest in cardiology in busy clinical environment.  

Her main research interest is focused on studying changes in cardiac geometry and function in cardiovascular disease. Aigul’s PhD thesis looking at cardiac remodelling in hypertension received numerous awards and distinctions at international level. Dr Baltabaeva has an experience of a core-lab cardiologist for multicentre European study looking at regression of hypertrophic cardiomyopathy in patients with Friedreich's ataxia. Currently Dr Baltabaeva is a principal investigator of major study looking at the incidence of significant mitral valve incompetence in acute heart failure. She maintains close connections with native Kyrgyzstan and just completed observational research study in remote rural district on the prevalence of cardiac disease amongst indigenous population.  

 

 


 

Mike Mahmoudi

 

Mike Mahmoudi

My research interests are the role of DNA damage and repair mechanisms in the pathogenesis of atherosclerosis as well as the potential for utilising circulating micro-RNAs in elucidating the pathophysiology of isolated coronary calcification. 

I am currently the principal investigator of a study examining the expression of genes involved in the DNA damage and repair-signaling pathways in peripheral blood mononuclear cells (PBMCs) in patients with coronary artery disease and determining whether the expression of such genes can be correlated with plaque anatomy as assessed with frequency-domain optical coherence tomography. 

I am also the principal investigator of a study investigating the potential for a “micro-RNA-signature” in patients with isolated coronary artery calcification as measured by CT coronary angiography. microRNAs are isolated from PBMCs for microarray analysis to predict potential micro-RNA targets and to examine the molecular/signalling pathways that characterise the pathophysiology of isolated coronary artery calcification in humans.

Publications

Original articles

1. Ota H, Mahmoudi M, Torguson R, Satler LF, Suddath WO, Pichard AD, Waksman R (2015). Safety and efficacy of everolimus-eluting stents for bare-metal in-stent restenosis. Cardiovasc Revasc Med, 16, 328-330

2. Tian W, Mahmoudi M, Lhermusier T, Pendyala LK, Kiramijyan S, Saar M, Ota H, Chen F, Torguson R, Suddath WO, Satler LF, Pichard AD, Waksman R (2015). Clinical outcomes of first- and second-generation drug-eluting stents in patients undergoing rotational atherectomy for heavily calcified coronary lesions. Cardiovasc Revasc Med, 16, 147-150

3. Ota H, Mahmoudi M, Kitabata H, Torguson R, Chen F, Satler LF, Suddath WO, Pichard AD, Waksman R (2015). Safety and efficacy of limus-eluting stents and balloon angioplasty for sirolimus-eluting in-stent restenosis. Cardiovasc Revasc Med, 16, 84-89

4. Williams TM, Waksman R, De Silva K, Jaques A, Mahmoudi M (2015). Ischemic preconditioning-an unfulfilled promise. Cardiovasc Revasc Med, 16, 101-108

5. De Silva K, Mahmoudi M (2015). Isolated coronary artery aneurysms presenting with ST-elevation myocardial infarction – a case of when less is more. Coron Artery Dis, 26, 88-90

6. Zeb M, Mahmoudi M, Garty F, Bannister C, Reddiar R, Nicholas Z, Crouch R, Heyworth J, Curzen N (2014). Detection of regional myocardial ischemia by a novel 80-electrode body surface Delta map in patients presenting to the emergency department with cardiac sounding chest pain. Eur J Emerg Med, 21, 89-97

7. Delhaye C, Kpogbemabou N, Modine T, Lemesle G, Staels B, Mahmoudi M, Tailleux A, Luc G, Bauters C, Lablanche J (2013). Long-term prognostic value of pre-procedural adiponectin levels in patients undergoing percutaneous coronary intervention. Inter J Cardiol, 168, 4921-4924

8. Mahmoudi M, Delhaye C, Waksman R (2012). Hypothermia therapy: Neurological and Cardiac Benefits. J Am Coll Cardiol, 17, 197-210

9. Mahmoudi M, Hauville C, Gaglia MA, Sardi G, Torguson R, Xue Z, Satler LF, Suddath  WO, Pichard AD, Waksman R (2012). The impact of intra-aortic balloon counter-pulsation on in-hospital mortality in patients presenting with anterior ST-elevation myocardial infarction without cardiogenic shock. Cardiovasc Revasc Med, 13, 328-330

10. Mahmoudi M, Harden S, Abid N, Peebles C, Nicholas Z, Jones T, McKenzie D, Curzen N (2012). Toponin positive chest pain with unobstructed coronary arteries: Definitive differential diagnosis using cardiac MRI. Br J Radiol, 85, e461-466

11. Mahmoudi M, Waksman R (2012). Glycoprotein IIb/IIIa inhibitors and bivalirudin in patients undergoing percutaneous coronary intervention. Minerva Cardioangiol, 60, 95-100

12. Maluenda G, Ben-Dor I, Gaglia MA, Wakabayashi K, Mahmoudi M, Sardi G, Laynez-Carnicero A, Torguson R, Xue Z, Margulies AD, Suddath WO, Kent KM, Bernardo NL, Satler LF, Pichard AD, Waksman R (2012). Clinical outcomes and treatment after drug-eluting stent failure: the absence of traditional risk factors for in-stent re-stenosis. Circ Cardiovasc Interv, 5, 12-19

13. Ben-Dor I, Maluenda G, Mahmoudi M, Torguson R, Xue Z, Bernardo NL, Lindsay J, Satler LF, Pichard AD, Waksman R (2012). A novel, minimally invasive access technique versus standard 18-gauge needle set for femoral access. Catheter Cardiovasc Interv, 79, 1180-1185

14. Mahmoudi M, Waksman R (2012). Bifurcation stenting: The current state of play. Cardiovasc Revasc Med, 13, 51-57

15. Wakabayashi K, Pakala R, Mahmoudi M, Watanabe T, Mori H, Iso Y, Suzuki H (2012). Novel technologies and future perspectives of drug eluting stents. Translational Med, S:7

16. Mahmoudi M, Hill P, Xue Z, Torguson R, Ali G, Boyce SW, Baffi AS, Corso PJ, Waksman R (2011). Patients with severe asymptomatic carotid artery stenosis do not have a higher risk of stroke and mortality following coronary artery bypass surgery. Stroke, 42, 2801-2805  

17. Mahmoudi M, Delhaye C, Wakabayashi K, Ben-Dor I, Gonzalez M, Maluenda G, Gaglia M, Torguson R, Xue Z, Satler L, Suddath W, Kent K, Pichard A, Waksman R (2011). Outcomes after unrestricted use of everolimus-eluting stent compared to paclitaxel- and sirolimus-eluting stents. Am J Cardiol, 107, 1757-1762 

18. Mahmoudi M, Syed A, Ben-Dor I, Gonzalez M, Maluenda G, Gaglia M, Sardi G, Wakabayashi K, Torguson R, Xue Z, Satler L, Suddath W, Pichard A, Waksman R (2011). Safety and efficacy of clopidogrel reloading in patients on chronic clopidogrel therapy who present with an acute coronary syndrome and undergo percutaneous coronary intervention. Am J Cardiol, 107, 1779-1782

19. Mahmoudi M, Delhaye C, Wakabayashi K, Torguson R, Xue Z, Satler L, Suddath W, Kent K, Pichard A, Waksman R (2011). Integrelin in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction. Journal of Interv Cardiol, 24, 351-356

20. Mahmoudi M, Delhaye C, Waksman R (2011). Safety and efficacy of drug-eluting and bare-metal stents in acute coronary syndrome. Cardiovasc Revasc Med, 12, 385-390

21. Gaglia MA JR, Torguson R, Pakala R, Xue Z, Sardi G, Mahmoudi M, Suddath W, Kent K, Satler LF, Pichard A, Waksman R (2011). Relation of body mass index on-treatment (clopidogrel+aspirin) platelet reactivity. Am J Cardiol, 108, 766-771

22. Belle L, Mahmoudi M, Delhaye C, Ben-Dor I, Maluenda G, Gaglia M, Torguson R, Satler LF, Pichard A, Waksman R (2011). Do Patients with drug-eluting stent thrombosis have a similar prognosis to patients presenting with ST-elevation myocardial infarction of de novo lesions? Journal of Interv Cardiol, 24, 320-325 

23. Wakabayashi K, Delhaye C, Mahmoudi M, Belle L, Ben-Dor I, Gaglia MA, Satler LF, Kent KM, Pichard AD, Lindsay J, Waksman R (2011). Impact of drug-eluting stent type on periprocedural myocardial necrosis. Eurointervention, 7, 136-142

24. Wakabayashi K, Romaguera R, Laynez-Carnicero A, Maluenda G, Ben-Dor I, Sardi G, Mahmoudi M, Gonzalez MA, Delhaye C, Torguson R, Xue Z, Suddath WO, Satler LF, Kent KM, Pichard AD, Lindsay J, Waksman R (2011). Impact of smoking on acute phase outcomes of myocardial infarction. Coron Artery Dis, 22, 217-222   

25. Ben-Dor I, Mahmoudi M, Pichard AD, Satler LF, Waksman R (2011). Optical coherence tomography – A new imaging modality for plaque characterisation and stent implantation. Journal of Interv Cardiol, 24, 184-192

26. Mahmoudi M, Syed A, Waksman R (2011). The role of percutaneous circulatory assist devices in acute myocardial infarction and high-risk percutaneous coronary intervention in the 21st century. Cardiovasc Revasc Med, 12, 237-242

27. Gaglia MA Jr, Torguson R, Xue Z, Gonzalez MA, Ben-Dor I, Maluenda G, Mahmoudi M, Sardi G, Wakabayashi K, Kaneshige K, Suddath WO, Kent KM, Satler LF, Pichard AD, Waksman R (2010). Effect of insurance type on adverse cardiac events after percutaneous coronary intervention. Am J Cardiol, 107, 675-680

28. Gaglia MA Jr, Torguson R, Gonzalez MA, Ben-Dor I, Maluenda G, Collins SD, Syed AI, Delhaye C, Wakabayashi K, Belle L, Mahmoudi M, Hanna N, Xue Z, Kaneshige K, Suddath WO, Kent KM, Satler LF, Pichard AD, Waksman R (2010). Correlates and consequences of gastrointestinal bleeding complicating percutaneous coronary intervention. Am J Cardiol, 106, 1069-1074

29. Mercer J, Cheng K, Figg N, Gorenne I, Mahmoudi M, Griffin J, Vidal-Puig A, Logan A, Murphy MP, and Bennett MR (2010). DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res, 107, 1021-1031

30. Mahmoudi M, Waksman R (2010). Drug-eluting stents for acute coronary syndromes: Should the labelling be expanded. Interv Cardiol, 2, 249-252

31. Mahmoudi M, Gorenne I, Mercer J, Figg N, Littlewood T, and Bennett MR (2008). Statins utilize a novel NBS-dependent pathway to accelerate DNA repair in vascular smooth muscle cells. Circ Res, 103, 712-725 

32. Mahmoudi M, Curzen NP, and Gallagher PJ (2007). Angiogenesis: the role of inflammation and infection. Histopathology, 50, 535-546

33. Mercer J, Mahmoudi M, and Bennett MR (2007). DNA damage, p53, apoptosis and vascular disease. Mut Res, 621, 75-86

34. Mahmoudi M, Mercer J, and Bennett MR (2006). DNA damage and repair in atherosclerosis. Cardiovascular Research, 71, 259-268

35. Mahmoudi M, McDonagh S, Poole-Wilson S, and Dubrey SW (2003). Obstacles to the initiation of beta-blockers for heart failure in specialized clinic within a district general hospital. Heart, 89, 442-444

36. Meyer T, Nelstrop AE, Mahmoudi M, and Rustin GJS (2001). Weekly cisplatin and oral etoposide as treatment for relapsed ovarian cancer. Ann Oncol, 12, 1-5 

37. Rustin GJS, Van Hippelstein M, Nelstrop AE, Mahmoudi M, and Meyer T (2001). Use of CA-125 to define progression of ovarian cancer in patients with persistently elevated levels. J Clin Oncol, 19, 4054-4057

 

Dr Michael Wood MBBS, BSc, PhD, FRCP


Michael wood

Michael Wood is the Clinical lead for Respiratory Medicine at Ashford and St Peters Hospitals (ASPH) and a Training Programme Director for Core Medical Training at Health Education Kent, Surrey and Sussex. He qualified from King’s College London and trained in and around London including specialist training at University College Hospital, The Royal Free Hospital and the London Chest Hospital. He won a Cancer Research UK Clinical Research Fellowship and gained his PhD in 2005, following research into Malignant Mesothelioma and tumour cell signalling inhibition, at the centre For Respiratory Research, UCL. After completion of his specialist training, he undertook further training in interventional bronchoscopy in Perth, Australia before returning to the UK to take up a consultant post in 2006. He has set up a highly successful endobronchial ultrasound service at ASPH and helped develop new real-time cytology techniques for bronchoscopy. There are several pharmaceutical trials running at ASPH concurrently with which he is involved, in the treatment of asthma, chronic obstructive pulmonary disease and soon to start trials with treatments of non-tuberculous mycobacterial disease and planned trails in pulmonary fibrosis. He has presented research at National and International Respiratory meetings.

Professor Pankaj Sharma

DirectorofICR

Professor Pankaj Sharma is a consultant neurologist at Imperial College Healthcare NHS Trust.

Professor Sharma holds a University of London Chair of Neurology at Royal Holloway. He is a former British Heart Foundation Clinician Scientist at Cambridge and a Fulbright Scholar at Harvard Medical School. He holds double doctorates from both the University of Cambridge and University of London. Most recently he led the internationally renowned Imperial College Cerebrovascular Research Unit at Imperial College London.

Professor Sharma’s research seeks to use genetics, genomics and proteomics to advance human understanding of cerebrovascular disease in three key areas: prediction, diagnosis and treatment of stroke at the molecular level.  He has a particular interest in the genetics of stroke in ethnic minorities, particularly South Asians and Middle Eastern populations.

Kate Sargeant

Kate sargentKate is the manager of ICR2UL and is responsible for its day to day operations. In addition, Kate is the main contact person for events and lectures that are handled by the institute.

She has extensive experience in event organisation and has been a Personal Assistant for 15 years in the commercial sector. 


She is also the Executive Assistant to ICR2UL Director, Professor Pankaj Sharma.


 

Senior Lecturers:
Dr David Cartwright  - Biochemistry
Dr Gulam Patel – General Rheumatology
Dr Riyaz Kaba – Cardiology
Dr Gwen Wark - Consultant Clinical Scientist and Scheme Organiser
Dr Sapna Sharma - Senior Lecturer in Medicine


Doctoral Student/Research Fellow:

  • Dr Ioana Cotlarciuc

 Research Fellow/Trial Manager:

  • Tasmin Patel

Phd and MSc (Current)

  • Charif Sada
  • Dr Jack Stewart
  • Dr Otar Lazariashvili

 

 

 

 

 Surrey Health Partners 
 
 
 

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